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日本药学会第109届年会医药品化学部会交流论文136篇,主要围绕着新药与开发的有关问题进行探讨。从脑神经系统、心血管循环系统、抗变态反应、抗癌等方面的药物研制、构效关系,发表了各自不同的见解。1.脑神经系统1.1 脑机能改善药脑机能改善药的评价法,一般是以益智作用为标准。武田药品公司的石原氏根据异吲哚[2.1-d]喹啉骨架,发现具有剂量依赖关系的强大益智作用的dimethylaminomethyl衍生物。但是此次筛选结果的有关详细药理作用没有说明,今后应注意其药效评价。另一
Japanese Society of Pharmacy 109th Annual Conference of Medicines Chemistry Department will exchange 136 papers, mainly around the new drug and development issues to be explored. From the brain nervous system, cardiovascular system, anti-allergy, cancer and other aspects of drug development, structure-activity relationship, published their different views. 1. Cerebral Nervous System 1.1 Brain Function Improving drug brain function Improving drug evaluation method is generally based on the function of puzzle. Ishihara of Takeda Pharmaceutical Co., Ltd. According to the isoindole [2.1-d] quinoline skeleton, a dimethylaminomethyl derivative was found to have a powerful puzzle in a dose-dependent manner. However, the screening results of the detailed pharmacological effects did not explain the future should pay attention to its efficacy evaluation. another