烷化剂以及能够代谢生成烷化剂的化合物,包括环境中重要的亚硝基类物质,构成了一组重要的致癌原和诱变剂。它们可以攻击细胞DNA分子中的许多部位,除了与脱氧核糖形成糖苷键的N原子和环外氨基上的N原子外,几乎碱基上所有的N、O原子都是烷化剂攻击的目标,DNA双螺旋骨架磷酸二 Alkylating agents, as well as compounds that metabolize to alkylating agents, including nitroso, which are important in the environment, constitute a group of important oncogenic and mutagenic agents. They can attack many parts of the cellular DNA molecule. Almost all N and O atoms in the base are targets of alkylating attack, except for the N atom which forms the glycosidic bond and the N atom outside the exocyclic amino group of the deoxyribose sugar. DNA double helix framework phosphate two