肺功能研究在国外已有60年的历史,近年来发展很快,特别是对小气道功能的研究及其测定试验的发展,已引起国内外学者的普遍重视。所谓小气道系指直径在2毫米或2毫米以下的气道,当发生病理性狭窄时,在呼气过程中可以出现早期关闭,导致通气与血流比率失常,因而发生气体交换障碍。Macklom 提出凡是具有这同一病理基础的疾病,统称为“小气道疾患”。鉴于早期病理改变尚处于可逆阶段,临床上早期常无症状和体征,而常规肺功能检查又不易发现,故探索小气道疾病的早期诊断方法,成为各国 Pulmonary function research in foreign countries for 60 years of history, developed rapidly in recent years, especially for the study of small airway function and the development of measurement tests, has attracted widespread attention of scholars at home and abroad. The so-called small airway means the diameter of 2 mm or 2 mm below the airway, when the pathological stenosis occurs during the expiratory early shutdown can occur, resulting in abnormal ventilation and blood flow rate, resulting in gas exchange disorders. Macklom proposed that all have the same pathological basis of the disease, collectively referred to as “small airway disease.” In view of the early pathological changes are still in a reversible stage, often asymptomatic clinically early symptoms and signs, and routine pulmonary function tests are not easy to find, it is to explore the early diagnosis of small airway disease and become a national