目的：探讨细胞因子在胃十二指肠疾病中的作用机理。方法：应用 Ｅ Ｌ Ｉ Ｓ Ａ 法对３０例慢性浅表性胃炎（急性期）、３０例消化性溃疡患者胃粘膜组织中细胞因子 Ｉ Ｌ１、 Ｉ Ｌ８及 Ｔ Ｎ Ｆα活性进行了测定。结果：慢性急性期浅表性胃炎患者胃粘膜中 Ｉ Ｌ１、 Ｉ Ｌ８及 Ｔ Ｎ Ｆα活性明显高于对照组（ Ｐ＜００１）；消化性溃疡患者明显高于对照组（ Ｐ＜ ００１）；幽门螺杆菌阳性疾病组明显高于阴性疾病组（ Ｐ＜ ００１）；其中消化性溃疡组 Ｉ Ｌ８活性明显高于慢性胃炎组（ Ｐ＜ ００１）。结论：细胞因子在慢性胃炎、消化性溃疡疾病发生发展中起一定作用。 Objective: To explore the mechanism of action of cytokines in gastroduodenal diseases. Methods: E L I S A method of 30 cases of chronic superficial gastritis (acute phase), 30 cases of peptic ulcer gastric mucosal tissue cytokines IL-1, IL-8 and T N F  α activity The measurement was carried out. Results: The activities of I L1, I L8 and T N Fα in gastric mucosa of patients with chronic superficial gastritis were significantly higher than those of the control group (P <001). The patients with peptic ulcer were significantly higher than those of the control Group (P <001); Helicobacter pylori positive disease group was significantly higher than the negative disease group (P <001); peptic ulcer group I L8 activity was significantly higher than the chronic gastritis group (P <0  01). Conclusion: Cytokines play a role in the development of chronic gastritis and peptic ulcer diseases.