论文部分内容阅读
目的 观察养阴化瘀中药对大鼠实验性高脂血症血及肝脏脂质代谢的影响。方法 采用高胆固醇饮食饲喂大鼠造成高脂血症模型 ,予以养阴化瘀中药灌胃 ,实验结束时取血及肝脏测试其脂质含量 ,并与基础饲料喂养及西药灌胃治疗对照观察。结果 中药、西药治疗组血胆固醇和低密度脂蛋白含量明显低于造模组 (P <0 .0 1 )、高密度脂蛋白及其亚型明显高于造模组 (P <0 .0 1 ) ,肝脏匀浆胆固醇含量亦明显低于造模组 (P <0 .0 1 ) ,且中药组高密度脂蛋白及其亚型亦高于西药组 (P <0 .0 5)。结论 养阴化瘀中药可明显降低血及肝脏组织匀浆中胆固醇含量 ,提示养阴化瘀中药可调整脂蛋白代谢 ,防止高脂血症和动脉粥样硬化的发生发展
Objective To observe the effect of nourishing yin and resolving phlegm medicine on blood lipids and hepatic lipid metabolism in experimental hyperlipidemia rats. Methods A high-cholesterol diet was fed to rats to induce a hyperlipidemia model. The nourishing yin and phlegm and blood stasis were given to the stomach. The blood and liver were tested for lipid content at the end of the experiment, and compared with basal feed and western medicine. . Results The contents of blood cholesterol and low density lipoprotein in the traditional Chinese medicine and western medicine treatment groups were significantly lower than those in the modeling group (P < 0.01), high density lipoprotein and its subtypes were significantly higher than those in the model group (P <0. The liver homogenate cholesterol content was also significantly lower than that in the model group (P < 0.01), and the high-density lipoprotein and its subtypes in the Chinese medicine group were also higher than those in the western medicine group (P <0.05). Conclusion Nourishing yin and resolving phlegm medicine can significantly reduce the cholesterol content in blood and liver homogenate, suggesting that nourishing yin and resolving phlegm medicine can regulate lipoprotein metabolism and prevent the development of hyperlipidemia and atherosclerosis.