Aim:To investigate the clinical characteristics of patients with Peyronie’s disease(PD)and diabetes mellitus(DM).Methods:During an 8-year period,a total of 307 men seen at our outpatient clinic were diagnosed with PD.Clinicalcharacteristics,penile deformities and the erectile status of patients with PD and DM together(n=102)were retro-spectively analyzed and compared to patients with PD alone with no risk factors for systemic vascular diseases(n=97).Results:The prevalence of PD among men with DM and sexual dysfunction was 10.7%.The mean ageof diabetic patients with PD was(55.9±8.9)years;in the no risk factor group it was(48.5±9.0)years(P<0.05).The median duration of DM was 5 years.The majority of diabetic patients with PD(56.0%)presented in the chronicphase(P<0.05),and they were more likely to have a severe penile deformity(>60°)than the no risk factor group(P<0.05).In the diabetic group,the most common presenting symptom was penile curvature(81.4 %),followedby a palpable nodule on the shaft of the penis(22.5%)and penile pain with erection(14.7 %).A total of 19.6 % ofpatients were not aware of their penile deformities in the diabetic group.Erectile function,provided by history and inresponse to intracavernosal injection and a stimulation test,was significantly diminished in patients with PD and DM(P<0.05).Conclusion:DM probably exaggerates the fibrotic process in PD.Diabetic patients with PD have ahigher risk of severe deformity and erectile dysfunction(ED).PD seems to be a silent consequence of DM andshould be actively sought in diabetic men.(Asian J Androl 2006 Jan;8:75-79) Aim: To investigate the clinical characteristics of patients with Peyronie’s disease (PD) and diabetes mellitus (DM). Methods: during an 8-year period, a total of 307 men seen at our outpatient clinic were diagnosed with PD. Clinicalinical Characteristics, penile deformities and the erectile status of patients with PD and DM together (n = 102) were retro-spectively analyzed and compared to patients with PD alone with no risk factors for systemic vascular diseases (n = 97). Results: The prevalence of PD among men with DM and sexual dysfunction was 10.7%. The mean age of diabetic patients with PD was (55.9 ± 8.9) years; in the no risk factor group it was (48.5 ± 9.0) years 5 years. Majority of diabetic patients with PD (56.0%) presented in the chronicphase (P <0.05), and they were more likely to have a severe penile deformity (> 60 °) than the no risk factor group In the diabetic group, the most common presenting symptom was penile curvature (81.4%), followed by a palpable nodule on the shaft of the penis (22.5%) and penile pain with erection (14.7%). A total of 19.6% of patients who did not aware of their penile deformities in the diabetic group. Erectile function, provided by history and inresponse to intracavernosal injection and a stimulation test, was significantly diminished in patients with PD and DM (P <0.05) .Conlusion: DM probably exaggerates the fibrotic process in PD. Diabetic patients with PD have ahigher risk of severe deformity and erectile dysfunction (ED). PD seems to be a silent consequence of DM and should be actively sought in diabetic men. (Asian J Androl 2006 Jan; 8: 75-79)