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目的:探讨重组人白介素2联合顺铂治疗老年卵巢癌导致恶性腹腔积液的疗效及安全性。方法:15例老年女性卵巢癌患者伴发恶性腹腔积液,经腹腔留置管引流积液干净后腹腔内注射重组人白介素2和顺铂控制腹水。结果:腹水完全缓解(CR)4例(26.7%),部分缓解(PR)6例(40%)有效(CR+PR)10例(66.7%),无进展(NC)1例(6.6%)进展(PD)4例(26.7%);少数病例出现发热及恶心不适。结论:重组人白介素2联合顺铂治疗老年卵巢癌导致恶性腹腔积液安全有效,能延长换生存期,改善生存质量。
Objective: To investigate the efficacy and safety of recombinant human interleukin-2 combined with cisplatin in the treatment of elderly patients with malignant ascites due to ovarian cancer. Methods: Fifteen elderly female patients with malignant ascites were treated with malignant ascites by intraperitoneal injection of recombinant human interleukin-2 and cisplatin. RESULTS: Six patients (26.7%) had complete remission (CR) of ascites, 10 (66.7%) had CR (6 cases) and 6 (6.6%) had progression-free Progress (PD) in 4 cases (26.7%); a few cases of fever and nausea. Conclusion: Recombinant human interleukin-2 combined with cisplatin is safe and effective in treating elderly patients with malignant ascites due to ovarian cancer. It can prolong the life-span and improve the quality of life.