论文部分内容阅读
目的探讨新疆汉族鼻咽癌患者HLA-A*02等位基因及其亚型的表达与鼻咽癌发病的关系。方法采用聚合酶链反应/序列特异性引物(PCR-SSP)的方法对63例新疆汉族鼻咽癌患者和51名汉族健康志愿者HLA-A等位基因进行分析,比较2组HLA-A*02等位基因及其亚型的差异。结果鼻咽癌患者共检出HLAA*02等位基因51个(频率39.7%),健康人群检出HLA-A*02等位基因17个(频率16.7%),2组比较差异有统计学意义(P=0.002);鼻咽癌患者共检出7个HLA-A*02等位基因亚型,健康人群检出4个等位基因亚型,2组比较差异无统计学意义(P>0.05),各亚型构成比比较差异无统计学意义(P>0.05)。结论HLA-A*02等位基因与新疆汉族鼻咽癌患者的发病有关,新疆鼻咽癌患者HLA-A*02等位基因亚型分布存在自身特点。
Objective To investigate the relationship between the expression of HLA-A * 02 alleles and their subtypes in nasopharyngeal carcinoma patients and the pathogenesis of nasopharyngeal carcinoma in Xinjiang. Methods The HLA-A alleles of 63 Chinese Han patients with NPC and 51 healthy Han volunteers were analyzed by polymerase chain reaction / sequence specific primers (PCR-SSP). The HLA-A * 02 alleles and their subtypes. Results There were 51 HLA-A * 02 alleles (frequency 39.7%) in NPC patients and 17 HLA-A * 02 alleles (16.7%) in healthy subjects. The difference between the two groups was statistically significant (P = 0.002) .There were 7 alleles of HLA-A * 02 alleles in nasopharyngeal carcinoma patients and 4 alleles alleles in healthy subjects (P> 0.05 for both groups) ), There was no significant difference in the constituent ratio of each subtype (P> 0.05). Conclusions HLA-A * 02 allele is associated with the pathogenesis of NPC in Xinjiang Han people. There is a unique feature of HLA-A * 02 allele distribution in Xinjiang NPC patients.