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本研究应用酶联免疫吸附试验(ELISA)检测了103例乙型肝炎各型患者及26倒乙肝病毒(HBV)携带者血清中可溶性白细胞介素2受体(sIL-2R)水平,并结合临床资料进行分析。结果发现:各型患者及HBV 携带者sIL-2R 水平均明显高于正常对照(P<0.01～0.001),其升高程度与病情轻重呈正比,在去除危重患者酶—胆分离时谷丙转氨酶(ALT)过低的影响后,sIL-2R 水平与ALT 有良好的正相关关系(r=0.38.p<0.05);作者认为sIL-2R 能够较好地反映疾病的活动状况,动态观察血清sIL-2R 水平的变化,对判断和评价HBV 感染后的病情演变及免疫失衡状态具有重要意义。
In this study, serum interleukin 2 receptor (sIL-2R) levels of 103 patients with hepatitis B and 26 carriers of hepatitis B virus (HBV) were detected by enzyme-linked immunosorbent assay (ELISA) Data analysis. The results showed that the levels of sIL-2R in all kinds of patients and HBV carriers were significantly higher than those in normal controls (P <0.01-0.001), and the level of sIL-2R was positively correlated with the severity of disease. In the removal of alanine aminotransferase SIL-2R was positively correlated with ALT (r = 0.38, p <0.05). The authors suggested that sIL-2R could better reflect the disease activity status, the dynamic observation of serum sIL -2R levels of changes in the judgment and evaluation of HBV infection after the evolution and immune imbalance in the state of great significance.