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[目的]探讨MDR1和Ki67在胃癌中表达的临床意义。[方法]应用免疫组织化学方法检测100例胃癌组织中MDR1及Ki67的表达。[结果]MDR1和Ki67在胃癌组织中的表达高于癌旁组织,而与年龄、性别、组织学类型、浸润深度以及淋巴结转移均无相关性。MDR1与Ki67之间也无明显相关性。[结论]MDR1和Ki67都不能作为胃癌病人判断预后和临床化疗耐药的单一指标。
[Objective] To investigate the clinical significance of MDR1 and Ki67 expression in gastric cancer. [Method] Immunohistochemistry was used to detect the expression of MDR1 and Ki67 in 100 cases of gastric cancer. [Results] The expression of MDR1 and Ki67 in gastric cancer tissues was higher than that in paracancerous tissues, but not with age, gender, histological type, depth of invasion and lymph node metastasis. There was also no significant correlation between MDR1 and Ki67. [Conclusion] Neither MDR1 nor Ki67 can be used as a single indicator of prognosis and clinical chemoresistance in patients with gastric cancer.