目的 :探讨胆汁酸对血压影响的多面性及其可能机制。方法 :检测高血压病患者血压控制前后的血浆总胆汁酸水平 ,给予大鼠小和中等剂量的外源性胆酸 ,观察动脉血压的变化 ,以及其心脏超微结构的变化。结果 :高血压病患者的血浆总胆汁酸水平升高并随血压的降低而降低 ;给予大鼠小剂量外源性胆酸血压升高 ,中等剂量时血压无变化 ;给予小剂量外源性胆酸大鼠心脏超微结构变化包括肌小节排列紊乱 ,灶性裂断 ,线粒体变性及坏死。结论 :胆汁酸参与了血压的调节 Objective: To explore the multi-faceted effect of bile acid on blood pressure and its possible mechanism. Methods: Plasma total bile acid levels were measured before and after blood pressure control in hypertensive patients. Small and medium doses of exogenous bile acids were given to rats. Changes of arterial blood pressure and ultrastructural changes were observed. Results: The plasma total bile acid level was elevated in patients with essential hypertension and decreased with the decrease of blood pressure. The rats given low-dose exogenous bile acid increased, while the middle-dose blood pressure did not change. Ultrastructural changes in acid rat hearts include disorganized muscle segments, focal dehiscence, mitochondrial degeneration and necrosis. Conclusion: Bile acids are involved in the regulation of blood pressure