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目的 :研究 82例葡萄球菌感染患者的临床特点、药物敏感性及葡萄球菌感染的治疗。方法 :82例均为住院患者 ,分析患者的原发病和诱因 ,将本组分离获得的 99株菌分为甲氧西林耐药金黄色葡萄球菌 (MRSA)或甲氧西林敏感金黄色葡萄球菌 (MSSA)、甲氧西林耐药凝因酶阴性葡萄球菌 (MRCNS)及甲氧西林敏感凝固酶阴性葡萄球菌 (MSCNS) 4类 ,并总结不同葡萄球菌感染的抗菌治疗。结果 :本组 82例均有原发疾病和诱因 ,后者如手术创伤、腔静脉置管、气管插管合并机械通气等。重症MRSA和MRCNS感染首选万古霉素 (或去甲万古霉素 )治疗 ,MSSA和MSCNS对 β内酰胺类抗生素与酶抑制剂复合剂疗效满意。本组 77例痊愈 ,5例失访。结论 :本研究提示对存在明显原发疾病的住院患者应警惕葡萄球菌感染之可能 ,对葡萄球菌感染必须获得每例患者的药敏资料 ,按药敏试验结果选择用药。
Objective: To study the clinical features, drug sensitivity and staphylococcal infection in 82 patients with staphylococcal infection. Methods: 82 cases were hospitalized patients, the analysis of the primary disease and incentives in patients with this group were isolated 99 strains of methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant coagulase-negative Staphylococcus aureus (MRCNS) and Methicillin-sensitive coagulase-negative Staphylococcus aureus (MSCNS), and summarized the antimicrobial therapy of different staphylococcal infections. Results: The group of 82 patients had primary diseases and incentives, the latter such as surgical trauma, vena cava catheterization, intubation and mechanical ventilation. Severe MRSA and MRCNS infection preferred vancomycin (or norvancomycin) treatment, MSSA and MSCNS on β-lactam antibiotics and enzyme inhibitors complex efficacy. The group of 77 patients recovered, 5 cases were lost. Conclusion: This study suggests that hospitalized patients with obvious primary diseases should be alert to the possibility of staphylococcal infection. For patients with staphylococcal infection, the susceptibility data of each patient must be obtained, and the drug should be selected according to the drug susceptibility test results.