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目的:观察α-干扰素口含片治疗慢性乙肝患者,在改善肝脏功能与血清HBV标志物的疗效。方法:随机分为二组,治疗组30例,给予肝灵素片,一天1片,临睡前口含治疗;对照组35例,予α-2b干扰素针300万单位,肌注,隔日1次,疗程均持续半年。结果:治疗组肝功能复常率80%,HBeAg转阴率53%,HBV-DNA转阴率60%;对照组分别为83%、60%、66%,两者差异无显著性意义(P>0.05)。结论:小剂量干扰素口含给药治疗慢性乙型肝炎与较大剂量肌注治疗,临床疗效相近,但其费用低,副反应轻,使用方便。
OBJECTIVE: To observe the therapeutic effect of interferon-alpha buccal tablets on patients with chronic hepatitis B in improving liver function and serum HBV markers. Methods: Randomly divided into two groups, the treatment group of 30 cases, given Liver Granules, a day, before going to sleep with mouth treatment; control group of 35 cases, to interferon α-2b 3 million units, intramuscular injection, every other day 1 times, treatment continued for six months. Results: The recovery rate of liver function in treatment group was 80%, the negative rate of HBeAg was 53%, and the negative rate of HBV-DNA was 60% in the treatment group; 83%, 60% and 66% in the control group respectively. There was no significant difference between the two groups > 0.05). Conclusion: Small dose interferon oral administration of chronic hepatitis B and larger doses of intramuscular injection therapy, clinical efficacy similar, but its low cost, side effects of light, easy to use.