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目的:探讨肾癌肺转移灶空泡样变的CT表现与血管靶向治疗的关系及预后影响。方法:回顾性分析2例转移性肾透明细胞癌经过分子靶向药物pazopanib治疗后肺转移灶出现空泡样改变的相关病例资料。结果:1例治疗5个月后因肝转移灶出现进展而停药,辅助化疗无改善10个月后疾病进展死亡;另1例出现自发性气胸后终止服药,2个月后出现病情进展死亡。结论:肾癌肺转移灶的空泡样变可能与分子靶向药物的应用有关,这种变化提示肿瘤的发展具有不确定性,应予以重视。
Objective: To investigate the relationship between CT manifestations and vascular targeted therapy in patients with renal cell carcinoma with metastasis of lung metastases and prognosis. Methods: Two cases of metastatic renal clear cell carcinoma were retrospectively analyzed for their vacuolar changes after metastatic renal cell carcinoma treated with the molecular targeted drug pazopanib. Results: After one month of treatment, the progress of liver metastasis was stopped and the progress of the chemotherapy was stopped after adjuvant chemotherapy. The other one died of spontaneous pneumothorax and the disease progressed after two months . Conclusion: The vacuolization of lung metastasis of renal cell carcinoma may be related to the application of molecular targeted drugs. This change suggests that the development of tumor is uncertain and should be taken seriously.