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用端氨基聚乳酸做引发剂,在DMF中引发Nε-苄氧羰基-L-赖氨酸酐(Lys(Z)-NCA)聚合,合成了端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸两嵌段共聚物.以端羧基聚乙二醇经NHS活化与端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸偶联,合成了聚(乳酸-b-Nε-苄氧羰基-L-赖氨酸-b-乙二醇)三嵌段聚合物.利用IR、1H-NMR、GPC和TEM对它们的结构、形态进行了表征,结果表明,所合成的分子量可控、分子量分布窄(Mw/Mn=1.07)的嵌段共聚物,酰化反应产率达70%以上.同时聚乙二醇和Nε-苄氧羰基-L-赖氨酸被引入到聚乳酸主链中,在聚合物侧链脱保护后有望改善聚乳酸的细胞亲和性。
Using terminal amino polylactic acid as initiator, Nε-benzyloxycarbonyl-L-lysine anhydride (Lys (Z) -NCA) was induced to polymerize in DMF to synthesize terminal amino poly (Nε-benzyloxycarbonyl- Acid) -b-polylactic acid diblock copolymer was synthesized by coupling carboxyl-terminated polyethylene glycol with N-terminal poly (Nε-benzyloxycarbonyl-L-lysine) Poly (lactic acid-b-Nε-benzyloxycarbonyl-L-lysine-b-ethylene glycol) triblock polymer.The structures and morphologies of the polymers were characterized by IR, 1H-NMR, GPC and TEM, The results showed that the yield of acylation reaction was more than 70% for the block copolymer with controlled molecular weight and narrow molecular weight distribution (Mw / Mn = 1.07) .At the same time polyethylene glycol and Nε-benzyloxycarbonyl-L- Amino acids are introduced into the polylactic acid backbone, which is expected to improve the cellular affinity of polylactic acid after deprotection of the polymer side chains.