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蛋白尿是各类肿瘤的一种较不常见但又已被公认的并发症,且蛋白尿常常很严重。组织学研究显示最常存在有膜性肾病,但在淋巴瘤病人则发现有典型的微小病变。在1例结肠癌病人的肾小球中已检出有肿瘤的产物,另在1例恶性黑素瘤和肾病综合征病人的肾脏曾沈脱出肿瘤抗原。从网状内皮系肿瘤病人死后尸检所获得的肾组织,发现在肾小球含有 C3、免疫球蛋白和电子致密沉积物,提示有亚临床的免疫复合物沉积。这些变化已证实见于死于肠肿瘤的病人。低浓度的蛋白尿可见于晚期肿瘤和肾外癌肿的病人。Framingham 的研究工作证明蛋白尿与死亡率
Proteinuria is a less common but recognized complication of all types of cancer, and proteinuria is often severe. Histological studies have shown that there is the most common membranous nephropathy, but patients with lymphoma found typical small lesions. Tumor products have been detected in the glomerulus of one patient with colon cancer and the tumor antigen has also been shed in the kidney of one patient with malignant melanoma and nephrotic syndrome. Renal tissue autopsied from post-mortem reticuloendothelial tumors found to contain C3, immunoglobulins and electron dense deposits in the glomerulus suggesting the deposition of subclinical immune complexes. These changes have been confirmed in patients who die of intestinal tumors. Low concentrations of proteinuria can be found in patients with advanced and extrarenal cancer. Framingham’s research shows proteinuria and mortality