论文部分内容阅读
肾内存在血管活性的调节系统,对保持肾脏血循环内环境的稳定起着重要作用。血管紧张素Ⅱ和交感神经活性为肾缩血管因素;相反,前列腺素和激肽为肾扩血管因素。肝硬化腹水患者常因肾血管收缩而出现肾血浆流量(RPF)和肾小球滤过率(GFR)的自发性下降,称为功能性肾衰或肝-肾综合征,常发生在对利尿剂治疗无效的腹水病例,预后不良。测定尿中激肽释放酶的活性可反映其在肾脏的合成。本研究旨在测定肝硬化腹水伴或不伴功能性肾衰患者的尿激肽释放酶的活性(UKalV),同时测定血浆肾素活性(PRA)、血浆去甲肾上腺素浓度(NE)和尿前列腺素E_2(UPGE_2V)。对象及方法:正常对照11名为第Ⅰ组。肝硬化腹
The presence of a vasoactive regulatory system in the kidney plays an important role in maintaining the stability of the environment within the renal bloodstream. Angiotensin II and sympathetic activity are neovascular factors; in contrast, prostaglandins and kinins are renal vasodilator factors. Patients with cirrhosis and ascites often have a spontaneous drop in renal plasma flow (RPF) and glomerular filtration rate (GFR) due to renal vasoconstriction, a condition known as functional renal failure or hepatorenal syndrome, often occurring in diuresis Invalid treatment of ascites cases, the prognosis is poor. Determination of urinary kallikrein activity can reflect its synthesis in the kidneys. The aim of this study was to determine the activity of urinary kallikrein (UKalV) in patients with cirrhosis with or without functional renal failure and to determine plasma renin activity (PRA), plasma norepinephrine (NE), and urine Prostaglandin E_2 (UPGE_2V). Subjects and Methods: Normal control 11 were group Ⅰ. Cirrhosis of the abdomen