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目的:研究不同浓度的异丙酚对大鼠顶区、额区、枕区和丘脑腹后内侧核(VPM)脑电近似熵(ApEn)和关联维数(D2)的影响.方法:48只雄性SD大鼠随机分为4组(n=12),分别在左右顶区、额区、枕区和丘脑VPM埋置硬膜外和深部电极,连续监测自发EEG.记录20min清醒状态的基础EEG后,持续静脉输注10g/L异丙酚,浓度依次为400,500,600,700,800,900μg/(kg·min),每个浓度持续输注10min,取最后2min的EEG进行后期分析,计算不同异丙酚浓度时各脑区的ApEn和D2.埋置电极进行EEG监测的前1wk,分别测量使大鼠翻正反射消失和夹尾反射消失的异丙酚浓度.结果:随着异丙酚药物浓度的增加,左右顶区、额区、枕区和丘脑的ApEn和D2均逐渐降低.所有大鼠均在500～600μg/(kg·min)时翻正反射消失,在800～900μg/(kg·min)时夹尾反射消失,产生以上不同麻醉效应的异丙酚浓度对应的各脑区ApEn和D2均低于清醒状态.结论:异丙酚可浓度依赖地降低顶区、额区、枕区和丘脑VPM活动的复杂程度,ApEn和D2是敏感的与不同麻醉效应相关的非线性EEG参数.
Objective: To study the effects of different concentrations of propofol on the ApEn and correlation dimension (D2) of the parietal lobe, frontal area, occipital region and hypothalamic ventrolateral medulla (VPM) in rats.Methods: 48 The male SD rats were randomly divided into 4 groups (n = 12), and the epidural and deep electrodes were implanted in the left and right parietal, frontal, occipital and hypothalamus VPM respectively, and the spontaneous EEG was monitored continuously. The basal EEG After continuous intravenous infusion of 10g / L propofol, followed by 400,500,600,700,800,900μg / (kg · min), continuous infusion of each concentration for 10min, take the last 2min EEG for post-analysis, calculate the concentration of different propofol Brain area of ApEn and D2. Embedded electrodes for EEG monitoring before 1wk, were measured to make the rat disappearance of right reflex and clamp tail reflex disappeared propofol concentration.Results: With the increase of propofol concentration, about ApEn and D2 in the apical, frontal, occipital and thalamus gradually decreased, all of them disappeared at 500 ~ 600μg / (kg · min), and disappeared at 800 ~ 900μg / (kg · min) Tail reflex disappeared, resulting in more than the different anesthetic effects of propofol concentrations corresponding brain regions ApEn and D2 were lower than the awake state.Conclusion: Propofol can Reduce dependence parietal, frontal, occipital region and the complexity of the thalamus VPM activities, ApEn and D2 are sensitive nonlinear EEG parameters associated with the different anesthetic effects.