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目的 探讨镁对老年急性心肌梗死 (AMI)患者QT离散度 (QTd)的影响。方法 随机分组、单盲处理、前瞻性研究 ,观察 60例AMI患者 (用镁治疗 3 0例 ,常规治疗 3 0例 )治疗前后QTd及RR间期、改良校正QT离散度 (QTLcd)、最大QT间期 (QTmax)、最小QT间期 (QTmin)的变化。结果 试验组及对照组治疗前后 1天的RR间期、QTd、QTLcd、QTmax及QTmin均无差异 (P >0 0 5 ) ;治疗后第 3天试验组RR间期、QTmin较对照组延长(P <0 0 5 ) ,QTd、QTLcd较对照组缩小 (P <0 0 5 ) ,两组QTmax无差异 (P >0 0 5 ) ;治疗 1周时试验组RR间期及QTmin较对照组延长 ( P <0 0 5 ) ,QTd和QTLcd较对照组缩小 ( P <0 0 5 ) ,两组QTmax无差异 ( P >0 0 5 ) ;治疗 2周时RR间期、QTd和QTLcd、QTmax两组无差异 (P >0 0 5 ) ,QTmin试验组较对照组延长 (P <0 0 5 ) ,血镁试验组较对照组升高 (P <0 0 5 )。结论 镁通过缩小AMI患者QTd ,使心肌复极化趋向同步 ,有利于防止恶性心律失常的发生 ,减少心肌梗死的病死率
Objective To investigate the effect of magnesium on QT dispersion (QTd) in elderly patients with acute myocardial infarction (AMI). Methods Randomized, single-blind, and prospective study was conducted to investigate the relationship between QTd and RR interval, QTDQ, QTD and QT in 60 patients with AMI (30 cases treated with magnesium and 30 cases treated routinely) Interval (QTmax), minimum QT interval (QTmin) changes. Results There was no difference in RR interval, QTd, QTLcd, QTmax and QTmin between the two groups before and after treatment (P> 0.05). On the third day after treatment, the RR interval and QTmin in the experimental group were longer than those in the control group QTd and QTLcd were significantly smaller than those in the control group (P <0.05), but there was no significant difference in QTmax between the two groups (P> 0.05). The RR interval and QTmin in the experimental group were longer than those in the control group (P <0.05), QTd and QTLcd were smaller than those in the control group (P <0.05), there was no difference in QTmax between the two groups (P> 0.05). The RR interval, QTd, QTLcd and QTmax (P> 0.05). The QTmin test group was longer than the control group (P <0.05), and the serum magnesium test group was higher than the control group (P <0.05). Conclusions Magnesium can reduce myocardial infarction mortality by reducing QTd in AMI patients and synchronizing myocardial repolarization.