作者根据慢性非甲非乙型肝炎患者的肝活检结果和血清ALT的变化研究了三种α-2b干扰素治疗方案持续18个月的疗效及肝活检结果与血清ALT之间的关系。 参试者为1989年～1991年期间的非甲非乙型肝炎患者。诊断依据为肝活检结果和血清ALT异常(大于正常值1.5倍)至少持续1年。所有患者均接受α-2b干扰素3MU,皮下注射,每周3次,疗程6个月。此后将患者随机分成3组:第1、2组分别接受α-2b干扰素3MU、1MU,皮下注射,每周3次, Based on the results of liver biopsy and serum ALT in patients with chronic non-A, non-B hepatitis, we investigated the efficacy of three interferon-alpha-2b regimens for 18 months and the relationship between liver biopsy results and serum ALT. The participants were non-A, non-B hepatitis patients from 1989 to 1991. The diagnosis is based on liver biopsy results and abnormal serum ALT (greater than 1.5 times normal) for at least 1 year. All patients received α-2b interferon 3MU subcutaneously three times a week for 6 months. After that, the patients were randomly divided into 3 groups: group 1 and group 2 received interferon alpha-2b 3MU, 1MU, subcutaneously three times per week,