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目的:通过检测兰州地区健康体检者空腹血脂水平了解本地区人群血脂水平现状及血脂异常情况,建立本地区血脂参考值。方法:采用全自动生化分析仪检测兰州市2328名健康体检者,血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。比较不同年龄、性别血脂水平差异。结果:本地区2328名被检者,女性TC平均(4.54±0.94)mmol/L,TG中位数1.24mmol/L、HDL-C平均(1.34±0.26)mmol/L、LDL-C平均(2.61±0.76)mmol/L;男性TC平均(4.52±0.84)mmol/L、TG中位数1.56mmol/L mmol/L、HDL-C平均(1.20±0.23)mmol/L LDL-C平均(2.76±0.72)mmol/L,血脂水平随年龄增加逐渐升高(P<0.05)。血脂参考范围为女性TC:2.70~6.38 mmol/L、TG:0.52~3.66 mmol/L、HDL-C:0.83~1.85 mmol/L、LDL-C:1.12~4.10 mmol/L男性:TG:2.87~6.17 mmol/L、0.65~4.00 mmol/L、0.75~1.65 mmol/L、1.35~4.17 mmol/L。男性高TC、高TG、低HDL-C和高LDL-C患病率为18.2%、42.8%、19.6%和28%,女性高TC、高TG、低HDL和高LDL的患病率分别为22.1%、25.5%、2.7%和23.5%。结论:兰州地区血脂水平随年龄、性别、地区不同存在较大差异,临床上不能采用统一标准衡量,而应根据本地区建立的参考值诊断高脂血症。积极控制血脂水平、降低高脂血症患病率预防心脑血管疾病发生。
OBJECTIVE: To understand the status of blood lipids and the level of dyslipidemia in healthy people in Lanzhou by detecting the level of fasting blood lipid in healthy volunteers in Lanzhou. Establish reference value of blood lipids in this area. Methods: Totally 2328 healthy volunteers in Lanzhou were enrolled in this study. Serum cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol ). Compare different age, gender differences in blood lipid levels. Results: The mean of TC was (4.54 ± 0.94) mmol / L, the median of TG was 1.24 mmol / L, the average HDL-C was 1.34 ± 0.26 mmol / L, the average LDL-C was 2.61 ± 0.76) mmol / L; mean TC was (4.52 ± 0.84) mmol / L for male, 1.56 mmol / L for TG and 1.20 ± 0.23 mmol / L for HDL-C 0.72) mmol / L, blood lipid level increased with age (P <0.05). The reference range of blood lipids was TC: 2.70 ~ 6.38 mmol / L, TG: 0.52-3.66 mmol / L, HDL-C: 0.83-1.85 mmol / L, LDL-C: 1.12-4.10 mmol / L, 6.17 mmol / L, 0.65 ~ 4.00 mmol / L, 0.75 ~ 1.65 mmol / L, 1.35 ~ 4.17 mmol / L. The prevalence rates of high TC, high TG, low HDL-C and high LDL-C in males were 18.2%, 42.8%, 19.6% and 28% respectively. The prevalences of high TC, high TG, low HDL and high LDL in women were 22.1%, 25.5%, 2.7% and 23.5%. Conclusion: The level of blood lipids in Lanzhou area varies greatly with age, gender and area. Clinically, it can not be measured by a uniform standard, but should be diagnosed according to the reference values established in this area. Actively control blood lipid levels, reduce the prevalence of hyperlipidemia to prevent cardiovascular and cerebrovascular diseases.