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目的:评价口腔矫正器治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并勃起功能障碍(ED)患者的效果。方法:纳入OSAHS合并ED患者40例,依据患者OSAHS病情程度分为轻中度OSAHS组[A组,睡眠呼吸暂停低通气指数(AHI)≤30次/h,最低氧饱和度(SaO2)≥80%]和重度OSAHS组(B组,AHI>30次/h,SaO2<80%),应用口腔矫正器治疗3个月后,比较两组患者治疗前后AHI、最低SaO2、“性活动日志”(SEP)阳性回答率、勃起功能国际问卷5(IIEF-5)评分的变化。结果:共3例患者不能耐受口腔矫正器而放弃治疗,其余37例患者完成治疗,其中A组16例,B组21例。治疗3个月后,两组患者AHI均较治疗前显著降低[(14.2±6.6)次/h vs(21.4±7.3)次/h,(29.7±8.1)次/h vs(51.4±9.5)次/h,P<0.05];A、B组IIEF-5评分分别增加(1.12±1.27)、(3.36±2.48)分,A组增加显著低于B组(P<0.05);A组患者对SEP2和SEP3回答“是”的比例明显低于B组(37.5%vs 76.2%,25.0%vs 61.9%,P均<0.05)。结论:口腔矫正器治疗能改善OSAHS合并ED患者的勃起功能,对重度OSAHS合并ED患者的勃起功能改善更明显。
Objective: To evaluate the effect of orthodontic appliances in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) complicated with erectile dysfunction (ED). Methods: Forty patients with OSAHS complicated with ED were divided into mild and moderate OSAHS group [group A, sleep apnea hypopnea index (AHI) ≤30 times / h, minimum oxygen saturation (SaO2) ≥80 %] And severe OSAHS group (group B, AHI> 30 times / h, SaO2 <80%). After oral orthodontic treatment for 3 months, the AHI, the lowest SaO2, (SEP) positive rate of change, erectile dysfunction Questionnaire 5 (IIEF-5) score changes. Results: A total of 3 patients were unable to tolerate oral appliances and gave up treatment. The remaining 37 patients completed treatment, including 16 in group A and 21 in group B. After 3 months of treatment, AHI in both groups was significantly lower than that before treatment [(14.2 ± 6.6) / h vs (21.4 ± 7.3) / h, (29.7 ± 8.1) h / h vs (51.4 ± 9.5) (P <0.05); A group of patients with IIF-5 score increased (1.12 ± 1.27), (3.36 ± 2.48) points, A group increased significantly lower than the B group And “yes” in SEP3 were significantly lower than those in group B (37.5% vs 76.2%, 25.0% vs 61.9%, P <0.05 respectively). Conclusion: Oral orthodontic treatment can improve the erectile function of patients with OSAHS complicated with ED and improve the erectile function of severe OSAHS with ED.