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1949年Chasis等首先介绍应用氮芥治疗肾炎的成功经验,开始曾引起国内外临床广泛试用与介绍。但近十数年,国外对此报告甚少,已有被肾上腺皮质激素及其他细胞毒类药物取代之势,甚至有人认为,应用此药治疗肾炎已属“历史上的兴趣”。目前国内看法亦甚不一致,但近年来发表的中西医结合综合治疗肾炎的经验均以氮芥为主要治疗药物之一。
In 1949, Chasis first introduced the successful experience of application of nitrogen mustard in the treatment of nephritis and started to have extensive clinical trial and introduction at home and abroad. However, in the recent ten years, few reports have been made on this subject. Some have been replaced by adrenal cortical hormones and other cytotoxic drugs. Some people even think that the treatment of nephritis using this drug has become “a historical interest.” The current domestic opinion is also very inconsistent, but in recent years published integrated traditional Chinese and Western medicine treatment of nephritis experience are nitrogen mustard as one of the main therapeutic drugs.