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[目的]观察不同剂量静注人血免疫球蛋白治疗小儿毛细支气管炎的疗效。[方法]选取我院2006年7月～2008年7月期间住院的158例毛细支气管炎患儿,随机分为3组,其中综合治疗组(A组)50例、综合治疗+常规剂量静注人血免疫球蛋白组(B组)52例、综合治疗+大剂量静注人血免疫球蛋白组(C组)56例。对治疗前、后临床表现消失时间、治愈率进行疗效比较。[结果]大剂量人血免疫球蛋白和常规剂量的免疫球蛋白治疗小儿毛细支气管炎均能明显缩短患儿临床症状表现时间,治愈率高,与综合治疗组对照(P﹤0.01)。但大剂量组和常规剂量组之间并无差异(P﹥0.05)。[结论]大剂量和常规剂量人血免疫球蛋白均能缩短小儿毛细支气管炎的病程,提高治愈率,是治疗小儿毛细支气管炎的一种有效方法。
[Objective] To observe the effect of intravenous injection of human immunoglobulin in children with bronchiolitis. [Methods] A total of 158 children with bronchiolitis who were hospitalized from July 2006 to July 2008 in our hospital were randomly divided into three groups, including 50 cases in the comprehensive treatment group (group A) Fifty - two human immunoglobulin groups (group B) and 56 patients received combined therapy and high - dose intravenous injection of human immunoglobulin (group C). On the treatment before and after disappearance of clinical manifestations, cure rates were compared. [Results] High dose of human blood immunoglobulin and conventional dose of immunoglobulin in children with bronchiolitis can significantly shorten the performance of clinical symptoms in children with high cure rate, compared with the comprehensive treatment group (P <0.01). However, there was no difference between the high dose group and the conventional dose group (P> 0.05). [Conclusion] Both high-dose and conventional-dose human immunoglobulin can shorten the course of pediatric bronchiolitis and improve the cure rate. It is an effective method for the treatment of bronchiolitis in children.