血管紧张素转化酶2(ACE2)是RAS系统的成员之一,可催化血管紧张素Ⅱ(AngⅡ)生成血管紧张素(1-7)[Ang(1-7)],构成[ACE2-Ang(1-7)-Mas]轴,发挥舒血管的生物学效应,同时维持AngⅡ与Ang(1-7)的动态平衡。在心血管疾病的发生过程中,RAS系统被激活,ACE2基因表达和蛋白含量都发生了改变,对疾病发生、发展起了重要的作用,现就ACE2的特征及对心血管疾病的影响进行综述。 Angiotensin-converting enzyme 2 (ACE2) is a member of the RAS system that catalyzes the production of angiotensin (1-7) [Ang (1-7)] by angiotensin II (Ang2) 1-7) -Mas] axis, exerting the biological effects of relaxing blood vessels while maintaining the homeostasis of Ang II and Ang (1-7). In the process of cardiovascular disease, the activation of RAS system, ACE2 gene expression and protein content have changed, the occurrence and development of the disease has played an important role, now on the characteristics of ACE2 and its impact on cardiovascular disease are reviewed.