自1976年Crowson TD等报告了2例美国青年妇女口服盐酸四环素引起了食管溃疡的病例以来,对于口服药物引起食管溃疡的认识日益加深。1979年Collins FJ等在“药物引起的食管损伤”一文中,报告了18例因溴化依米波宁(emepronium bromide)和慢释放钾盐引起的食管溃疡;1980年Barrison IG、1981年McCloy E C等分别报告了服用四环素和萘呋胺酯(naftidrofuryl)引起食管溃疡的病例;1976年Evans K T也曾发表过有关论述。 Since 1976, when Crowson TD et al reported that two American young women oral administration of tetracycline hydrochloride caused esophageal ulcer cases, the awareness of oral drug-induced esophageal ulcer has deepened. In 1979 Collins FJ et al., “Drug-induced Esophageal Injury,” reported 18 cases of esophageal ulcers caused by emepronium bromide and slow-release potassium salts; 1980 Barrison IG, 1981 McCloy EC Et al reported cases of esophageal ulcer caused by tetracycline and naftidrofuryl, respectively; in 1976, Evans KT also published the relevant statement.