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流行病学、临床和实验室资料提示,胆汁酸及其副产物可能有导致结肠癌发病的作用。居住在结肠癌发病率高的工业发达国家的人其大便中的次级胆汁酸含量比居住在结肠癌发病率低的非洲和东方国家的人更高。同样,结肠癌的病人粪便中次级胆汁酸的含量比没有结肠癌的病人高。总之,次级胆汁酸(胆石酸和脱氧胆酸)在诱发动物实验性结肠癌中起着辅致癌原的作用。
Epidemiological, clinical, and laboratory data suggest that bile acids and their byproducts may contribute to the development of colon cancer. People living in industrial developed countries with high incidence of colon cancer have higher levels of sub-bile acids in their bowel than those living in African and Eastern countries with low incidence of colon cancer. Similarly, the level of secondary bile acids in feces from patients with colon cancer was higher than in patients without colon cancer. In conclusion, the secondary bile acids (cholic acid and deoxycholic acid) act as co-carcinogens in inducing experimental colon cancer in animals.