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口服降糖灵治疗糖尿病已广泛应用于临床,但长期服用所致乳酸酸中毒亦屡见报道。据统计1977年552例乳酸酸中毒患者中有306例是由于糖尿病服用双胍类降糖药所致。死亡率高(达50～80％),应予以足够的重视。现将本院遇到的1例降糖灵诱发严重乳酸酸中毒报告如下并结合文献加以讨论: 患者崔×,男,65岁,农民。因突然意识不清3小时来院,患者于入院前3小时曾恶心、呕吐、吐出咖啡样物400毫升,遂不省人事;10年来有溃疡病史,8年来患糖尿病、多饮、多食、多尿,一直服用降糖灵(6片/天,即150毫克/天)治疗。
Oral hypoglycemic treatment of diabetes has been widely used in clinical, but also reported long-term use of lactic acidosis. According to statistics, in 1977 552 cases of lactic acidosis in 306 patients are due to diabetes mellitus with biguanide hypoglycemic agents. High mortality (up to 50 ~ 80%), should be given sufficient attention. The hospital now encountered a hypoglycemic induced severe lactic acidosis reported as follows and combined with the literature to be discussed: Patient Cui ×, male, 65 years old, farmer. Due to sudden unconsciousness 3 hours to hospital, 3 hours before admission to patients with nausea, vomiting, spit out coffee samples 400 ml, then unconscious; 10 years of history of ulcers, 8 years of suffering from diabetes, polydipsia, more food and more Urine, has been taking hypoglycemic (6 / day, that is, 150 mg / day) treatment.