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1966年 Hopsu-Havu 及 Glenner 在鼠肝和肾中发现甘氨酰脯氨酸二肽氨肽酶(GPDA),它是一个水解甘氨酰脯氨酰β-萘酰胺的新的二肽萘酰胺酶。已发现患肝胆疾病的病人血清中此酶活性增加,胃癌时则降低;而肝癌时此酶活性的血清水平却未见报道。作者检查了233例肝胆疾病病人(包括59例肝癌(?)53例肝细胞癌及6例转移癌)和100例健康对照者
In 1966 Hopsu-Havu and Glenner found glycyl-proline dipeptidyl aminopeptidase (GPDA) in rat liver and kidney, a novel dipeptide naphthylamide that hydrolyzes glycyl-prolyl beta-naphthylamide Enzymes. It has been found that patients with liver and gallbladder disease serum increased activity of this enzyme, while gastric cancer decreased; and liver cancer serum levels of this enzyme activity has not been reported. The authors examined 233 patients with hepatobiliary disease (including 59 cases of hepatocellular carcinoma (?), 53 cases of hepatocellular carcinoma and 6 cases of metastatic carcinoma) and 100 healthy controls