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目的探讨低功率半导体激光对家兔神经功能恢复的影响。方法用 36只体重 2 .5kg左右的家兔随机分为 3,6 ,9和 12周 4个观察期组 ,每个观察期组随机分为半导体激光照射组 (各用家兔 5只 )和对照组 (各用家兔 4只 )。麻醉后 ,均切断左侧腓总神经 ,用 9/0尼龙单丝对端吻合神经外膜。各照射组在术后 1d开始照射家兔L5 ,6脊髓节段 ,照射激光输出功率为2mW ,每天照射 5min ,连续照射 7d。对照组不照射 ,均按期观察。结果术后 3周 ,可在照射组看到细小而稀少的再生轴突 ,对照组直到术后 6周才看到 (P <0 .0 1)。照射组的腓总神经潜伏速率均优于对照组 (P <0 .0 1) ,动作电位波幅照射组也优于对照组。展趾功能到术后 12周 ,照射组与侧健相同 ,对照组才恢复到照射组 6周的水平。结论低功率的半导体激光促进脊髓运动神经细胞功能 ,加速轴突再生
Objective To investigate the effect of low power semiconductor laser on neural recovery in rabbits. Methods Thirty-six rabbits weighing about 2.5 kg were randomly divided into 4 observation periods of 3, 6, 9 and 12 weeks. Each observation period was randomly divided into three groups: laser irradiation (5 rabbits) and Control group (each rabbit with 4). After anesthesia, the left common peroneal nerve was severed, and the 9/0 nylon monofilament was used to match the epineurium. The rabbits in each irradiation group were irradiated with L5, 6 spinal cord segments at 1 day after the operation, the laser output power was 2 mW, and the irradiation was performed for 5 min every day for 7 days. Control group did not irradiation, were observed on schedule. Results Three weeks after operation, small and sparse regenerating axons could be seen in the irradiation group, and the control group did not see until 6 weeks after operation (P <0.01). The peroneal nerve latency in irradiation group was better than that in control group (P <0.01), and the amplitude of action potential amplitude group was better than that of control group. Show toe function to 12 weeks after surgery, irradiation group and the side of the same, the control group was restored to the level of irradiation for 6 weeks. Conclusion Low-power semiconductor laser can promote spinal cord motoneuron function and accelerate axonal regeneration