论文部分内容阅读
目的:分析选择性5-羟色胺再摄取抑制剂(SSRI)所致不良反应的临床特征、相关因素,为临床用药提供参考依据。方法:检索1989-2008年国内文献库收载的SSRI不良反应资料,得到符合标准的病例77例,并按世界卫生组织(WHO)国际药品监测合作中心的不良反应分类方法进行分类、研究。结果:77例不良反应中,21～40岁患者较多(30例,38.96%);SSRI不良反应涉及的组织系统较多,以神经系统损害最常见(47例,56.63%);不良反应预后总体较好。结论:引发SSRI不良反应的原因很多,但正确认识并展开全方位的监测可以有效减少甚至避免不良反应的发生。
Objective: To analyze the clinical characteristics and related factors of adverse reactions induced by selective serotonin reuptake inhibitors (SSRIs), and to provide a reference for clinical use. Methods: The data of SSRIs collected in the domestic literature database from 1989 to 2008 were retrieved and 77 cases were eligible. The cases were classified and studied according to the adverse reaction classification method of the World Health Organization (WHO) International Center for Drug Control and Cooperation. Results: Among the 77 patients with adverse reactions, there were more patients 21 to 40 years old (30 cases, 38.96%). Adverse reactions of SSRI included more tissues and nervous system damage (47 cases, 56.63%), adverse reactions Overall better. Conclusion: There are many reasons for SSRIs adverse reactions, but to correctly understand and carry out a comprehensive monitoring can effectively reduce or even avoid the occurrence of adverse reactions.