中期细胞出现染色体异常似乎是肿瘤细??胞典型的显著特征之一。一般认为这是基因组不稳定性的表现。由于业已证明姊妹染色单体互换(SCE)对于致突变影响具有很高的敏感性;另一方面,在Bloom综合征中也反映出这种基因组的不稳定性,因此,本文旨在进一步研究白血病细胞与姊妹染色单体互换的相关性。作者研究了8例诊断为急性白血病而未 The appearance of chromosomal abnormalities in metaphase cells appears to be one of the prominent features of tumor cells. This is generally considered to be a manifestation of genomic instability. Because sister chromatid exchange (SCE) has been shown to be highly sensitive to mutagenic effects; on the other hand, this genome instability is also reflected in Bloom syndrome. Therefore, this article aims to further study. The correlation between leukemia cells and sister chromatid exchanges. The authors studied 8 cases diagnosed as acute leukemia