目的:通过检测外周血白细胞介素(IL)-17水平,探讨过敏性哮喘患者与健康人之间以及疾病不同严重程度之间IL-17表达水平的差异。方法:采用ELISA方法检测过敏性哮喘患者血浆中以及外周血单个核细胞(PB-MCs)培养上清液中IL-17的水平,并分析该促炎细胞因子与疾病不同严重程度之间的相关性。结果:过敏性哮喘患者血浆中以及PBMCs培养液上清中IL-17的水平均较健康对照组升高(P<0.05),且血浆中IL-17的水平随哮喘的严重程度增加而升高。结论:IL-17参与了哮喘的发生发展,血浆中的IL-17水平也许可以用来作为判断哮喘严重程度的一个参考指标。 OBJECTIVE: To detect the level of IL-17 in peripheral blood to explore the difference of IL-17 expression between allergic asthma patients and healthy individuals and between different severity of disease. Methods: The level of IL-17 in the supernatant of PBMC from peripheral blood of patients with allergic asthma was measured by ELISA. The correlation between the proinflammatory cytokines and different severity of disease was analyzed Sex. Results: The levels of IL-17 in plasma and PBMCs supernatant of patients with allergic asthma were significantly higher than those in healthy controls (P <0.05), and the levels of IL-17 in plasma increased with the severity of asthma . CONCLUSIONS: IL-17 is involved in the development of asthma. The level of IL-17 in plasma may be used as a reference index for judging the severity of asthma.