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目的 探讨缺氧性脑水肿豚鼠血浆内皮素和一氧化氮含量变化及其高压氧（ＨＢＯ） 干预治疗机制。方法 应用放免法和比色法检测豚鼠在急性缺氧性脑水肿及高压氧治疗前后血浆内皮素（ＥＴ） 与一氧化氮（ＮＯ） 含量变化。结果 急性缺氧后脑组织含水量、血浆ＥＴ 与ＮＯ 水平均有所上升，尤以ＮＯ 为著。ＨＢＯ 治疗可降低脑组织含水量、血浆ＮＯ 水平，但ＥＴ 水平明显增高。结论 急性缺氧性脑水肿病理过程中有ＮＯ 过量生成，ＨＢＯ 能减轻缺氧性脑水肿，其机制可能与抑制ＮＯ 生成及ＥＴ 增高相关。
Objective To investigate the changes of plasma endothelin and nitric oxide in guinea pigs with hypoxic cerebral edema and the mechanism of HBO intervention. Methods The changes of plasma endothelin (ET) and nitric oxide (NO) levels in guinea pigs before and after acute hypoxic cerebral edema and hyperbaric oxygen therapy were measured by radioimmunoassay and colorimetry. Results After acute hypoxia, brain water content, plasma ET and NO levels increased, especially for NO. HBO treatment can reduce brain water content, plasma NO levels, but ET levels were significantly higher. Conclusions There is excessive production of NO in the pathological process of acute hypoxic cerebral edema. HBO can reduce hypoxic cerebral edema, which may be related to inhibition of NO production and ET.