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氟苯桂嗪[Flunarizine,(4-FC_6H_4)_2CHN N-CH_2-CH=CHPh]为新的强效脑血管扩张剂,临床用于闭塞性动脉硬化症,能改善血流循环,其重要中间体为4,4′-二氟苯基氯甲烷(Ⅰ),据报道Ⅰ的合成步骤可综合如下:
Flunarizine [(4-FC_6H_4) _2CHN N-CH_2-CH = CHPh] is a new and potent cerebral vasodilator. It is clinically used in the treatment of arteriosclerosis obliterans and can improve blood circulation. Important intermediates Is 4,4’-difluorophenylchloromethane (I), the synthetic steps reported for I can be summarized as follows: