Angew.Chem.Int.Ed.2017,56,637~640Sarcandrolide J及Shizukaol D是两个具有代表性的[4+2]型乌药烷倍半萜二聚体天然产物,颇具合成挑战性.最近,基于修正的生源合成假说,四川大学化学学院刘波课题组成功实现了Sarcandrolide J及Shizukaol D的首次不对称全合成.以中间体1为原料,分别经11步合成亲双烯体3和呋喃共轭二烯前体6.两片段发生正常电子需求的 Angew.Chem.Int.Ed.2017,56,637~440Sarcandrolide J and Shizukaol D are quite typical natural enemies of the [4 + 2] type anther sesquiterpene dimer, and are quite synthetic. Recently, Revised hypothesis of biosynthesis of raw materials, the research group of Liu Bo, School of Chemistry, Sichuan University, succeeded in the first asymmetric total synthesis of Sarcandrolide J and Shizukaol D. The intermediate 1 was used as the starting material to synthesize dienophile 3 and furan conjugate 2 Precursor 6. The two fragments undergo normal electron demand