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分离九里香叶中具有抗炎镇痛活性的香豆素类化合物。利用小鼠扭体镇痛实验为活性跟踪动物模型,以硅胶色谱柱为分离手段,以波谱学为空间鉴定手段,并以小鼠扭体镇痛实验和二甲苯致耳朵肿胀实验为活性鉴定的动物模型。分离得到了6种香豆素类化合物,分别为蛇床子素、脱水长叶九里香内酯、橙皮内酯、伞形花内酯、东莨菪素、Murracarpin。药理学活性研究发现Murracarpin的抗炎镇痛活性最强。Murracarpin具有强抗炎镇痛活性,可能与其C-7位上的甲氧基,C-8位上的一个短的支链且都含有双键及醇羟基等结构有关。
Coumarin compounds with anti-inflammatory and analgesic activity in Grifola frondosa. The mice writhing analgesia experiment was taken as the animal model of the activity tracking, the silica gel column was used as the separation method, the spectroscopic method was used as the space identification method, and the activity was identified by the writhing analgesic test in mice and the ear swelling test in xylene Animal model Six kinds of coumarins were isolated, which were osthol, vinorelbine, hesperidin, umbelliferone, scopolamine and Murracarpin respectively. Pharmacological activity study found that Murracarpin strongest anti-inflammatory analgesic activity. Murracarpin possesses potent anti-inflammatory and analgesic activities and may be related to its methoxy group at C-7, a short branch at C-8 and both contain double bonds and alcoholic hydroxyl groups.