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通过建立高胆固醇血症兔模型，观察载脂蛋白（ａｐｏ）Ａ－Ⅳ和ａｐｏＡ－Ⅳ／卵磷脂（ＰＣ）脂质体等对高胆固醇血症兔主动脉平滑肌细胞（ＳＭＣ）内胆固醇的清除及对血清卵磷脂胆固醇酰基转移酶（ＬＣＡＴ）的激活作用。结果显示，ａｐｏＡ－Ⅳ／ＰＣ脂质体清除ＳＭＣ内胆固醇及激活ＬＣＡＴ的能力与ａｐｏＡ－Ⅰ／ＰＣ脂质体、高密度脂蛋白（ＨＤＬ）相似。提示，ａｐｏＡ－Ⅳ与ａｐｏＡ－Ⅰ一样，在胆固醇逆向转运过程中起重要作用；ａｐｏＡ－Ⅳ与ＰＣ人工合成的脂质体有可能代替天然ＨＤＬ而发挥防治动脉粥样硬化的作用。
To establish a model of hypercholesterolemia in rabbits and observe the effects of apo A-Ⅳ and apoA-Ⅳ / lecithin (PC) liposomes on the cholesterol removal in hypercholesterolemic rabbit aortic smooth muscle cells (SMCs) And the activation of serum lecithin cholesterol acyltransferase (LCAT). The results showed that apoA-IV / PC liposomes had the same ability to clear cholesterol and activate LCAT in SMC as apoA-I / PC liposome and high density lipoprotein (HDL). Tip, apoA-IV and apoA-I, plays an important role in the reverse cholesterol transport; apoA-IV and PC artificial liposomes may replace natural HDL and play the role of prevention and treatment of atherosclerosis.