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恩丹西酮(Ondanseton)治疗抗癌药物引起的恶心、呕吐反应72例,分三组观察。第1组为非顺氯铵铂(DDP),含ADM、CTX组。于化疗前给恩丹西酮,静注,8mg,次日口服恩丹西酮4mg,每日2次,共用1天。其疗效第1天100%;第2~3天为81.8%,96.9%;第4~5天为100%。第2组为含DDP组,输DDP之日静注恩丹西酮8mg,次日口服本药4mg,1日2次,连服2天,其疗效第1~3天分别为75.7%,81.8%,96.9%,第4~5天为100%。第3组亦为含有DDP加氟美松10mg,用法同第2组,其止吐疗效第1~3天为90.9%,第4~5天为100%。结果,恩丹西酮加氟美松的效果90.9%,比单用恩丹西酮组的疗效75.5%~96.9%优越。
Ondanseton treatment of anticancer drugs caused by nausea and vomiting in 72 cases, divided into three groups observed. The first group is non-cisplatin platinum (DDP), containing ADM, CTX group. Ondansetron before chemotherapy, intravenous injection, 8mg, oral administration of ondansetron 4mg the next day, 2 times a day for 1 day. The efficacy of the first day 100%; the first two days to 81.8%, 96.9%; the first four days to 100%. The second group was DDP group, DDP on the intravenous infusion of ondansetron 8mg, the next day oral administration of the drug 4mg, 1 day 2 times, and even served 2 days, the efficacy of 1 to 3 days were 75.7% , 81.8%, 96.9%, 100% on the 4th to 5th days. The third group also contains DDP plus dexamethasone 10mg, the same usage as Group 2, the antiemetic efficacy of 1 to 3 days 90.9%, 4 to 5 days to 100%. The results, ondansetron and dexamethasone 90.9%, than ondansetron alone group efficacy of 75.5% to 96.9% superior.