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本实验采用改进胃空肠吻合术法制备大鼠实验性返流性胃炎模型,观察病理组织学改变并测定了胃酸、胆汁酸、胃蛋白酶等胃液成分的含量。结果表明,胆胃胶囊能显著抑制胃粘膜充血、瘀血、水肿等病变,减轻炎细胞浸润及腺体增生,减少肠上皮化生;能提高总酸排出量、降低胆汁酸浓度、大剂量组使胃蛋白酶活性显著升高。另外还有抑制小鼠胃排空的作用。故认为胆胃胶囊的疗效可能主要是对胃粘膜的保护作用,这与吗丁啉及Cisapride作用机理不一样。
In this experiment, a modified gastrojejunostomy method was used to prepare a rat model of experimental reflux gastritis. Histopathological changes were observed and the contents of gastric juice such as gastric acid, bile acid and pepsin were determined. The results showed that the Shiwei capsule can significantly inhibit gastric mucosal congestion, blood stasis, edema and other diseases, reduce inflammatory cell infiltration and gland hyperplasia, reduce intestinal metaplasia; can increase total acid excretion, reduce bile acid concentration, high-dose group Pepsin activity was significantly increased. There is also the role of inhibition of gastric emptying in mice. Therefore, it is believed that the curative effect of gall bladder capsules may be mainly on the protection of gastric mucosa, which is not the same as the mechanism of action of domperidone and Cisapride.