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用特异的放射免疫方法测定血浆内皮素（ＥＴ），对２３例急性心肌梗塞（ＡＭＩ）、２６例冠心病心绞痛及９例冠心病心力衰竭（ＣＨＦ）病人进行动态观察。发现该３组病人在治疗前血浆内皮素水平均显著高于对照组（Ｐ＜０．０１）。ＡＭＩ组１周后降至正常。心绞痛组在心绞痛发作时，血浆内皮素最高，随症状缓解，１周内降至正常。ＣＨＦ组血浆内皮素与心衰程度有关，心功能Ⅳ级组明显高于Ⅲ级组（Ｐ＜０．０１），随心衰缓解皆有所降低，但下降速度较缓慢。此外，血浆内皮素与心肌缺氧、缺血及心功能状态密切相关，可作为冠心病发生、发展衍变的重要依据，并可用于急性心梗后的动态观察，用以观察治疗效果及判断预后。
Plasma endothelin (ET) was measured by specific radioimmunoassay, and 23 patients with acute myocardial infarction (AMI), 26 patients with coronary heart disease angina pectoris and 9 patients with coronary heart disease and heart failure (CHF) were observed. The plasma endothelin levels in these three groups were significantly higher than those in the control group before treatment (P <0.01). AMI group returned to normal after 1 week. Angina pectoris group angina pectoris, plasma endothelin highest, with the symptoms ease, reduced to normal within 1 week. Plasma endothelin level in CHF group was related to the degree of heart failure. The level of cardiac function in grade Ⅳ group was significantly higher than that in grade Ⅲ group (P <0.01), but the rate of decline was lower with CHF. In addition, plasma endothelin and myocardial hypoxia, ischemia and cardiac function is closely related to coronary heart disease can be used as an important basis for the development and evolution, and can be used for dynamic observation after acute myocardial infarction, to observe the therapeutic effect and to determine the prognosis .