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转化生长因子β(TGF-β)是广泛存在于体内的具有强大生物学活性的多效性细胞因子,在造血过程中发挥重要的作用。其作用特点可以归纳为:双向性、直接性、可逆性和剂量依赖性。通过TGF--βSmad信号转导途径,调控原始干/祖细胞细胞周期。TGF-β潜在的临床应用价值促使其体内外研究在国内外广泛而深入地进行。
Transforming growth factor beta (TGF-beta) is a potent and pleiotropic cytokine that widely exists in the body and plays an important role in hematopoiesis. Its role can be summarized as: two-way, direct, reversible and dose-dependent. Through the TGF - βSmad signal transduction pathway, regulate the cell cycle of primary stem / progenitor cells. The potential of clinical application of TGF-βprotein in vitro and in vivo research at home and abroad to carry out extensive and in-depth.