心脏传导系统(CCS)由几部分功能截然不同的亚单位在信号分子内皮素-1、神经调节蛋白-1和转导因子Nkx2.5、Tbx等参与的一系列精确的时空调节机制所组成,确保了正常心律和机体的血液流动;CCS分化过程的意外缺陷可能会导致严重的节律紊乱发生。对CCS各成分起源和诱导分化机制的深入研究将有助于在治疗中运用组织工程的有效方法来修复或重建心脏传导系统。 Cardiac conduction system (CCS) consists of a series of precise temporal and spatial regulation mechanisms involving several distinctly distinct subunits in the signaling molecules endothelin-1, neuregulin-1, and transduction factors Nkx2.5, Tbx, Ensures normal heart rhythm and body blood flow; unexpected defects in the process of CCS differentiation may result in severe rhythm disturbances. In-depth study of the origin and induction of differentiation of CCS components will help in the treatment of effective methods of tissue engineering to repair or rebuild the cardiac conduction system.