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本文采用反相高效液相色谱法,以标准布比卡因为内标测定利多卡因血药度。变异系数CV<5%,回收率为102.87%。应用本法对临床利多卡因硬膜外麻醉病人的血浓度进行了监测和药代动力学研究,平均血药浓度——时间曲线呈药代动力学血管外开放型二室模型,峰浓度Cmax4.18±2.18μg/ml,消除半衰期t1/2/β66.16min,达峰时间Tmax20±7min,测得最高浓度为9.32μg/ml,临床未见明显毒副反应发生。
In this paper, reversed-phase high performance liquid chromatography with standard bupivacaine lidocaine blood drug standard. CV <5%, the recovery rate was 102.87%. This method was used to monitor and pharmacokinetics of clinical lidocaine in patients with epidural anesthesia. The mean plasma concentration-time curve showed a two-compartment pharmacokinetic open-vessel model with a peak concentration of Cmax4 .18 ± 2.18μg / ml, the elimination half-life t1 / 2 / β66.16min, peak time Tmax20 ± 7min, the highest concentration of 9.32μg / ml, no obvious clinical side effects.