在慢性乙肝抗病毒治疗的策略制定过程中,先前的治疗较少考虑患者在疾病过程中所处的阶段,使得抗病毒治疗难以获得最佳的疗效。慢性HBV感染自然史尚未受到广泛重视的一个原因是其自然史处于动态变化中,在临床工作中难以找到理想的指标来标示疾病所处阶段以及预测患者预后。本文 In the development of strategies for the treatment of chronic hepatitis B virus antiviral therapy, previous treatments rarely consider the stage in which the patient is at the stage of the disease, making it very difficult to obtain the best possible response to antiviral therapy. One of the reasons why the natural history of chronic HBV infection has not been given much attention is that its natural history is in a dynamic state. It is difficult to find the ideal indicator in clinical work to indicate the stage of the disease and predict the prognosis of patients. This article