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目的研究胰腺癌组织中VEGF的表达与淋巴结转移的关系。方法对胰腺癌组织标本采用免疫组织化学染色(SP法),光镜下进行VEGF阳性细胞评分,用SPSS10.0统计软件进行统计学分析。结果胰腺癌组织中VEGF的表达阳性率为51%(18/35),评分2.71±1.41明显高于正常胰腺组织中VEGF的表达(0.5±0.55,P<0.01)。淋巴结转移组VEGF的表达(3.45±1.46)较未转移组明显增高(2.41±1.39,P<0.05)。VEGF的表达与其他胰腺癌临床分期和病理分期均无明显关系(P>0.05)。结论VEGF的表达与胰腺癌的淋巴结转移有密切关系,与胰腺癌的临床分期和病理分期无明显关系。
Objective To study the relationship between VEGF expression and lymph node metastasis in pancreatic cancer. Methods Immunohistochemical staining (SP method) was performed on pancreatic cancer tissue specimens. VEGF positive cells were scored under light microscope and analyzed by SPSS10.0 statistical software. Results The positive rate of VEGF expression in pancreatic cancer was 51% (18/35), and the score was 2.71 ± 1.41, which was significantly higher than that in normal pancreatic tissue (0.5 ± 0.55, P <0.01). The expression of VEGF (3.45 ± 1.46) in lymph node metastasis group was significantly higher than that in non-metastasis group (2.41 ± 1.39, P <0.05). There was no significant correlation between the expression of VEGF and other clinical stages and pathological stages of pancreatic cancer (P> 0.05). Conclusion The expression of VEGF is closely related to the lymph node metastasis of pancreatic cancer, but not to the clinical stage and pathological stage of pancreatic cancer.