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端粒酶与恶性肿瘤的发生、发展关系密切，是肿瘤治疗的一个新的靶点，细胞分化诱导剂抑制端粒酶活性的研究进展明显。本文介绍了维甲类化合物、维生素Ｄ３类化合物。茶多酚以及苦参碱等多种细胞分化诱导剂对端粒酶活性的影响。
Telomerase is closely related to the occurrence and development of malignant tumor, which is a new target of tumor therapy. The research on telomerase activity induced by cell differentiation inducer is progressing obviously. This article describes the retinoids, vitamin D3 compounds. Tea polyphenols and matrine and other cell differentiation inducer on the telomerase activity.