根据美国女泌尿科专家Gillespie医师的意见,间质性膀胱炎(IC亦称Hunner氏溃疡)的病因,有时正是用来治疗它的抗生素所引起的。 医学教材称此症为老年妇女的一种少见、无法治疗的疾病。Gillespie证实它不是一个疾病,而是几种疾患,最常见的是在没有感染的情况下用抗生素引起的。她注意到许多女病人述说她们的医师因怀疑膀胱炎而开抗生素。当用药后膀胱灼痛症状加剧时,医师一般就再开一种更强的抗生素,从而引起更痛的症状。Gillespie进行两年研究后发现,膀胱内面的表层起保护膀胱组织免受尿酸侵蚀的作用,当此保护屏障被破坏时,患者即可感到膀胱灼痛、压迫感或绞痛。 According to the American urologist Gillespie, the etiology of interstitial cystitis (IC, also known as Hunner’s ulcer) is sometimes caused by the antibiotics used to treat it. Medical textbooks say the disease is a rare, untreatable disease in older women. Gillespie confirmed that it is not a disease but rather a few disorders, the most common of which is caused by antibiotics in the absence of infection. She noted that many women reported that their physicians had opened antibiotics for suspected cystitis. When the symptoms of bladder burns increase after treatment, physicians generally re-open a stronger antibiotic, causing more painful symptoms. Gillespie’s two-year study found that the inside surface of the bladder protects the bladder tissue from uric acid attack, and when the protective barrier is damaged, the patient can feel bladder burning, pressure or cramping.