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目的分析甘肃省农村地区服用苯巴比妥治疗惊厥性癫痫患者的退组原因,探讨癫痫患者服药的依从性,提高患者的疗效和生活质量。方法对2010年1月─2013年12月退组的377例惊厥性癫痫患者追踪回访,填写调查表,对退组者的性别、年龄、退组时间及原因等情况进行统计学分析。结果使用苯巴比妥治疗管理的4 026例患者中有377例退出治疗、退组率为9.36%,女性退组率高于男性,差异有统计学意义(χ2=4.663,P<0.05);退组年龄集中在10岁~组、占退组总数的26.53%,各年龄组差异无统计学意义(χ2=3.453,P>0.05);退组时间多发生于治疗前三个月内,与其他时间退组者差异有统计学意义(χ2=31.082,P<0.05),第四个月后退组患者明显减少;退组原因主要有依从性差、外出打工和疗效差等,因依从性差而退组明显高于其他原因的退组(χ2=10.704,P<0.05)。结论甘肃省农村地区癫痫患者退组率女性高于男性,治疗前三个月内易退组,主要原因是患者依从性差;在今后的工作中,应加强对癫痫防治知识的宣传教育,特别是在入组治疗前及服药初期对患者及家属反复强调依从性的重要性,以提高患者的治疗效果。
Objective To analyze the causes of withdrawal from phenobarbital in patients with convulsive epilepsy in rural areas of Gansu Province and to investigate the compliance of medication in patients with epilepsy so as to improve the curative effect and quality of life of patients. Methods A total of 377 patients with convulsive epilepsy who were withdrawn from January 2010 to December 2013 were followed up. The questionnaires were filled in and statistical analysis was made on the gender, age, withdrawal time and causes of the patients. Results 377 of 4262 patients treated with phenobarbital were withdrawn from treatment. The withdrawal rate was 9.36%. The withdrawal rate of female was higher than that of male (χ2 = 4.663, P <0.05). The age of retreat group was concentrated in the age group of 10 years old, accounting for 26.53% of the total number of retreat group. There was no significant difference among all age groups (χ2 = 3.453, P> 0.05). The retreat group occurred within three months before treatment, There was significant difference between the other groups (χ2 = 31.082, P <0.05), and the number of patients in the fourth month was significantly decreased. The reasons for the group were poor compliance, poor working and poor efficacy, and poor compliance Group was significantly higher than other groups (χ2 = 10.704, P <0.05). Conclusions Female patients with epilepsy in rural areas of Gansu Province are higher than men in the withdrawal rate and easily withdrawn within three months before treatment, which is mainly due to the poor compliance of patients. In the future work, the publicity and education on epilepsy prevention and control knowledge should be strengthened, especially In the group before treatment and early medication for patients and their families repeatedly stressed the importance of compliance in order to improve the patient’s treatment.