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机体对不利的环境因素(如严寒、乏氧、外伤等)有一定适应能力,当受到这些“激原”(Stressor)作用时,能通过大脑皮层一下丘脑一垂体前叶一肾上腺这一神经体液调节系统,使其适应新的环境。因而,研究这类“应激”反应时必须注意到肾上腺皮质的功能。此外,某些垂体肾上腺系统疾病的病因探讨和诊断,也常依赖于皮质激素代谢物的分析,例如肾上腺性征异常征(Adrenogenital Syndrome)是合成皮质激素的某些酶类(21-羟化酶、11-β-羟化酶或 3-β-羟类固醇脱氢酶)有先天性缺损,以致皮质醇、醛固酮分泌过少,雄激素分泌过多所引起的征候群;由于病人的酶缺损种类和程度不同,其代谢中间物的异常堆积和
The body has some resilience to unfavorable environmental factors (such as cold, hypoxia, trauma, etc.). When subjected to these “Stressor” effects, it can pass through the cerebral cortex to the front of the hypothalamic-pituitary-adrenal gland Adjust the system to adapt to the new environment. Thus, the study of such “stress” response must pay attention to the function of the adrenal cortex. In addition, the etiology and diagnosis of some pituitary adrenal disorders are often dependent on corticosteroid metabolite analysis, such as Adrenogenital Syndrome, which is a synthesis of certain enzymes of the corticosteroid (21-hydroxylase , 11-β-hydroxylase or 3-β-hydroxysteroid dehydrogenase) have congenital defects, resulting in cortisol, aldosterone secretion is too small, and hyperandrogenism caused by symptoms; due to the type of patient’s enzyme deficiency And to varying degrees, the abnormal accumulation of metabolic intermediates and